Say Goodbye to Acne

INTRODCUTION:

Acne vulgaris (acne) the bane of teenage existence occurs almost universally in both young men and women in their teens and early 20s. It is almost ubiquitous in teenage years. The peak severity is in the late teenage years but acnes may persist into the third decade and beyond especially in females who may experience flare-ups before menstruation. The hormonal changes responsible for premenenstral bouts, with acne are responsible for breakouts some women experience when taking oral contraceptives, during pregnancy or while undergoing menopausal hormone therapy.

Although acne is not dangerous, it is unsightly and can have a negative psychological impact on adolescents particularly at a time when they are most anxious about their appearance. Consequently, they seek all sorts of advice and medication so as to curb this “ugly” incidence. Being so “mirror-conscious”, they strictly follow these medications to retain their beauty. To make this situation even worse, acne is rarely cured. However, its symptoms can be controlled; acne eruptions can be reduced and scarring can be minimized with proper care.

This scourge has stolen beauty from many faces, generated undue worries and anxiety among the younger population, and presented a myriad of “unanswered questions” to health workers. Hence it is necessary to proffer solutions, on how to reduce its incidence lest it becomes a source of global worry.

DEFINITION: WHAT IS ACNE?

Acne is an eruption, predominantly of the face, upper back, shoulder and chest composed of comedones, cysts, papules and pustules on an inflammatory base. Simply put, it is an inflammatory eruption involving the pilosebaceous apparatus. The common name Pimple is usually used to denote the inflammatory lesion of acne. This condition occurs ina majority of people during puberty or adolescence due to androgenic stimulation of sebum secretion with plugging of follicles by keratinization associated with proliferation of Propionibacterium acnes.

CAUSES:

The cause if multifactorial, but there are 3 major pathogenic factors that clearly summarize its aetiology.

* Elevated sebum excretion

* Infection with Propionibacterium acnes

* Blockage or occlusion of the pilosebaceous unit.

There is a clear relation between the severity of acne and sebum excretion rate. Acne does not occur in complete absence of sebum. Therefore, sebum excretion is necessary for the development of acne but not sufficient to cause acne on its own. Androgen stimulation greatly determines sebum excretion. This accounts for the onset of acne in teenage years. Progesterone also increases sebum excretion while oestrogens reduce it. In another development, the bacterium Propionibacterium acnes colonizes the pilosebaceous ducts and acts on the lipids to produce a number of proinflammatory factors. Finally, the occlusion of the pilosebaceous unit contributes to the development of acne.

Acne can be exacerbated, or even caused by a number of factors including:-

* Genetic susceptibility leading to the hyperconification of pilosebaceous duct and its blockage.

* High humidity, frequent or prolonged sweating.

* Local irritation, friction, rough or occlusion clothing, which can be conducive to lesion formation of acneprone individuals.

* Long term use of hair-care products that contain occlusive petroleum of liquid petroleum, causing acne along the hairline (sometimes “pomade acne”)

* Drug such as corticosteroids which can sensitive hair follicles and produce “steroid acne” and other systemic drugs like androgens, some oral contraceptives, halothane and thyroid preparations known to precipitate acne eruption.

* Oil-based cosmetics can be occlusive and plug the follicles.

* Prolonged exposure to sun, prolonged stress and other emotional extremes.

CLINICAL FEATURES:

Acne presents in areas rich in sebaceous glands such as the face, back, shoulder and sternal (chest) area. The cardinal features are open comedones (black heads) due to plugging of the pilosebaceous orifice by kertain or sebum or closed comedones (white heads) due to accretions of sebum abd keratin deeper in the pilosebaceous ducts.

* Inflammatory papules circumscribed solid elevation up to 100cm diameter on the skin, which may be pedunculassted, sessile or filiform.

* Pustules circumscribed superficial elevation of the skin (about 1cm diameter) containing purulent materials.

Other clinical variants of acne include infantile acne, conglobate acne, acne fulminans, follicular occlusion traid, steroid acne and oil acne each with its distinctive features.

TREATMENT:

Self treatment should be limited to those patients who have non-inflammatory acne of mild-to-moderate severity (ie eruptions are limited to white heads and black head). The role of a detmatologist in severe cases of inflammatory acne (consisting of papules, pustules and nodules) must be south.

Treatment is aimed at decreasing sebum production, bacterial proliferation, normalizing duct keratinization or decreasing inflammation. Management starts with paying attention to exacerbating factors.

Topical agents such as:

* Benzyol peroxide (a keratolytic agent) and Fretinoin (A topical retinoid) should be used in individuals with fairly minor disease (particularly those dominated by the presence of comedones).

* Patients with anything but minor degrees acne will require therapy with antibiotics (local or systemic). Local antibiotics widely used include Clindamycin or Erythromycin. The principal oral antibiotic is Oxytetracycline. Monocycline may be used if oxytetacycline’s response is inadequate.

* If these topical and systemic agents fail to produce a sufficient clinical response within 3-6 months, treatment with Isotretinoin is considered. Remember, these drugs have their different modes of administration and side effects therefore, the physician’s role on prescription and monitoring of treatment is very essential.

Good skin care habits are essential in the treatment and management of acne. These should be emphasized by health workers. They include:

* Avoidance of prolonged exposure to the sun.

* Patient’s should be encouraged to switch from oil to water-based skin care products. If the hair is oily, frequent shampooing with water-based shampoo should minimized hairline eruptions.

* Patients should wash their faces 2-3 times daily using warm water, a mild medicated or unmedicated facial soap and a soft wash-cloth.

* Mild abrasive soaps (such as those containing pumice, polyethylene or Aluminum oxide) can be helpful in removing the outer layer of dead skin cells.

* Squeezing, pinching or picking at acne lesions can aggrevate the condition and cause permanent scarring. Avoid this!

CONLCUSION

The understanding of the basic aetiology and underlying pathology of any form of sickness is a great step in the pursuit of an effective treatment. Improper understanding may “rubbish” a good scientific treatment formular, or elicit a wide- range of side effects. With these steps for acne, the beauty and cosmetic concern of every individuals will be achieved.

REFERENCES:

1. Barbara white Sax (2000): Acne and Wrinkles: Skin care for baby boomers and their kids; Pharmacy times (Oct. 2000); P. 55-57.

2. Christopher Haslett et al (2000): Davidson’s principles and practice of medicine, Churchill Livingstone; P. 1051-1082.

3. Kumar and Clark (2000): Clinical Medicine (5th Ed.); 1320.

4. Lippoincolt, Williams, Wilkins (1998); Steadman’s Medical Dictionary. (27th Ed.) p. 15-16.

By: Anyanwagu Uchenna Chidi

About the Author:

Spironolactone is generally prescribed as an “off label” acne treatment for women. This drug, though intended to help people with heart problems not zit problems, reduces the production of the hormone androgen. Androgen promotes excess facial oil secretion.

Less oil secretion limits the possibility of having clogged pores and acne flare-ups.

Spironolactone works as an androgen receptor blocker. This drug decreases androgen production in the ovaries and adrenal glands. Side effects from spironolactone can include breast tenderness and menstrual irregularity.

For this reason, doctors usually add oral contraceptives like Ortho Tri-Cyclen and Estrostephave to compliment acne treatments and ease potential spironolactone side effects. Ironically though, spironolactone is recommended for women who are not candidates for oral contraceptives.

So should a woman over 35 with acne go with spironolactone? According to the American College of Physicians, the answer is “No”.

In the 2004 May/June edition of the American College of Physicians (ACP) published a medical review of studies that tested the effectiveness of spironolactone for controlling hirsutism, acne, or both in fertile or postmenopausal women. The ACP review found insufficient evidence to recommend spironolactone as an acne treatment.

Nevertheless, Dr. Diane Thiboutot of Pennsylvania State University, Hershey uses spironolactone for female patients with acne accompanied by a suspected endocrine disorder.

For example, when a woman experiences a sudden onset of severe acne or acne that is linked with excessive facial hair growth, irregular menstrual periods, increased libido, dark patches of skin, deepening of the voice, insulin resistance and hair loss, spironolactone may be helpful.

Dr. Thiboutot noted that spironolactone “seems to control quite well those cystic-type nodules that they [women] get on their lower face and chin.”

Yet Dr. Julie C Harper Dr. Harper of the department of dermatology at the University of Alabama, Birmingham doesn’t recommend spironolactone so easily. Only if neither topical retinoids nor antibiotics have not worked for a woman’s case of acne would Dr. Harper then suggest using spironolactone for women over 35.

Author of “Acne Messages”, Naweko San-Joyz, says “A woman’s response to androgens is so varied that limiting herself to an androgen blockers like spironolactone certainly does not guarantee a cure, or even a quick treatment.”

San-Joyz adds that overproduction of androgens is just one step in a series of potential events that could lead to acne. Instead of hormonal manipulation with drugs, San-Joyz suggests women with acne regulate this conditional using food, stress control and greater awareness of potential acne triggers like environmental estrogens.

Women with acne have numerous treatments options. If a woman does decide to go with spironolactone, it’s best to get her prescription filled with her gynecologist rather that her general practitioner.

It’s most likely that the gynecologist will be more aware of how a patient may respond to hormonal treatments like spironolactone and oral contraceptives, thus making recovery faster.

By: Naweko San-joyz

About the Author: